Recombinant tissue-type plasminogen activator: An infarct-sparing effect beyond thrombolysis?
نویسندگان
چکیده
منابع مشابه
Coronary thrombolysis with recombinant human tissue-type plasminogen activator.
The thrombolytic potency and myocardial infarct--sparing potential of recombinant tissue-type plasminogen activator (rt-PA) were studied in electrocardiographically monitored, open-chest, anesthetized dogs. Localized coronary thrombosis was produced in the left anterior descending artery by endothelial injury and instillation of thrombin and fresh blood. After 2 hr of stable thrombotic occlusio...
متن کاملEffect of ultrasound on tissue-type plasminogen activator-induced thrombolysis.
BACKGROUND The efficacy of fibrinolytic therapy is limited by the small surface area of the clot that is available for the binding of the thrombolytic agent, such as tissue-type plasminogen activator (t-PA). We hypothesized that exposure of the clot to ultrasound during thrombolytic treatment could enhance lysis through perturbation of the thrombus, which would expose additional fibrin binding ...
متن کاملDual frequency ultrasound-enhanced tissue plasminogen activator thrombolysis in an in vitro human clot model
Introduction: Stroke causes death and disability in patients throughout the world. At present, the only FDA- approved drug for ischemic stroke is recombinant tissue plasminogen activator (rt- PA). Unfortunately, rtPA can cause intracerebral hemorrhage and must use within limited time window (within 3-4.5 hour after onset of stroke). Ultrasound with rtPA loaded liposomes (rtPA_L...
متن کاملOptimizing refolding condition for recombinant tissue plasminogen activator
Low molecular size additives such as L-arginine and the redox compounds have been used both in the culturemedium and in vitro refolding to increase recombinant proteins production. Additives increase proteinrefolding and yield of active proteins by suppressing aggregate formation or enhancing refolding process.In this work, a comparative study was performed on refolding of rec...
متن کاملCerebral Hemorrhages and Effect on Infarct Volume and Postischemic Endothelial Involvement of Thrombolysis in Recombinant Tissue Plasminogen Activator-Induced
Sophie Gautier, Olivier Petrault, Patrick Gele, Maud Laprais, Michelle Bastide, Anne Bauters, Function Cerebral Hemorrhages and Effect on Infarct Volume and Postischemic Endothelial Involvement of Thrombolysis in Recombinant Tissue Plasminogen Activator-Induced Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2003 American Heart Association, Inc. All rights reserved. is published by th...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1992
ISSN: 0735-1097
DOI: 10.1016/0735-1097(92)90163-h